Cross-validation of a non-invasive positron detector to measure the arterial input function for pharmacokinetic modelling in dynamic positron emission tomography

In recent years, there has been an increasing interest in clinical applications for dynamic positron emission tomography (dPET) [1 –6]. Welz et al. demonstrated a workflow where 18F-Fluoromisonidazole (FMISO) dPET was used to identify hypoxic regions in head and neck tumors prior to radiotherapy treatment planning [6]. These hypoxic regions were prescribed a higher dose than the rest of the tumor to combat the radio-resistant nature of hypoxic tumor cells. Preliminary results were promising, showing an increase in local–regional control.

Source: Physica Medica: European Journal of Medical Physics - July 1, 2020 Category: General Medicine Authors: Liam Carroll, Etienne Croteau, Gustavo Kertzscher, Otman Sarrhini, Vincent Turgeon, Roger Lecomte, Shirin A. Enger Tags: Original paper Source Type: research