The stability of carbapenems before and after admixture to PMMA-cement used for replacement surgery caused by Gram-negative bacteria

ConclusionsIn contrast to the results of meropenem and imipenem in solution, both antibiotics remain stable in solid form and mostly stable in the cement after PMMA polymerization. The low degradation levels of both antibiotics after exposure to temperatures  >  100 °C allow the conclusion that they can potentially be used for an application in PMMA cements.

Source: European Journal of Medical Research - August 17, 2020 Category: Research Source Type: research