Development and Clinical Validation of a 90-Gene Expression Assay for Identifying Tumor Tissue Origin

The accurate identification of tissue origin in patients with metastatic cancer is critical for effective treatment selection but remains a challenge. The aim of this study is to develop a gene expression assay for tumor molecular classification and integrate it with clinicopathologic evaluations to identify the tissue origin for cancer of uncertain primary (CUP). A 90-gene expression signature, covering 21 tumor types, was identified and validated with an overall accuracy of 89.8% (95% CI, 0.87 –0.92) in 609 tumor samples.

Source: Journal of Molecular Diagnostics - June 26, 2020 Category: Pathology Authors: Qing Ye, Qifeng Wang, Peng Qi, Jinying Chen, Yifeng Sun, Shichai Jin, Wanli Ren, Chengshu Chen, Mei Liu, Midie Xu, Gang Ji, Jun Yang, Ling Nie, Qinghua Xu, Deshuang Huang, Xiang Du, Xiaoyan Zhou Tags: Regular article Source Type: research