The Value of Serum Uncoupling Protein-2 Level for the Patients With Sepsis

Background: To investigate the potential utility of serum uncoupling protein-2 (UCP2) level as a biomarker in septic patients. Methods: Critically ill patients with diagnoses of sepsis—sepsis non-shock group (n = 20) and septic shock group (n = 53), and a control group (n = 15) were enrolled within 24 h of entry into the ICU. Serum levels of UCP2 were measured by enzyme-linked immunosorbent assay (ELISA) at ICU admission for all the groups and at ICU discharge for septic shock group. Clinical parameters and laboratorial tests (APACHE II, SOFA, lactate, etc.) were also collected. Results: Serum UCP2 concentrations on ICU admission were significantly increased in septic shock group and sepsis non-shock group, compared with control subjects (263.21 ± 29.99 vs. 115.96 ± 32.99 vs. 60.56 ± 10.05 pg/mL, P 246.52 pg/mL) had significantly increased 28-day mortality compared with those with lower UCP2 levels (
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research