IRF9 Affects the TNF-Induced Phenotype of Rheumatoid-Arthritis Fibroblast-Like Synoviocytes via Regulation of the SIRT-1/NF- κB Signaling Pathway

Conclusion: Silencing IRF9 curbs the activity of the NF- κB signaling pathway via up-regulating SIRT-1, to further suppress TNF-induced changes in the malignant features of RA-FLS, and the secretion of inflammatory cytokines, with the promoted apoptosis.Cells Tissues Organs
Source: Cells Tissues Organs - Category: Cytology Source Type: research