BrachyView: development of an algorithm for real-time automatic LDR brachytherapy seed detection.

BrachyView: development of an algorithm for real-time automatic LDR brachytherapy seed detection. Phys Med Biol. 2020 Aug 05;: Authors: Brennen TJ, Galli L, Cutajar DL, Alnaghy S, Bucci JA, Bece A, Enari K, Favoino M, Carriero M, Tartaglia M, Archer J, Lerch MLF, Rosenfeld AB, Petasecca M Abstract BrachyView is a novel in-body imaging system developed to provide real-time 12 intraoperative dosimetry for low dose rate prostate brachytherapy treatments. Seed positions 13 can be reconstructed after in-vivo implantation using a high-resolution pinhole gamma camera 14 inserted into the patient rectum. The obtained data is a set of 2D projections of the seeds on the 15 image plane. The 3D reconstruction algorithm requires the identification of the seed's centre 16 of mass. This work presents the development and techniques adopted to build an algorithm that 17 provides the means for fully automatic seed centre of mass identification and 3D position 18 reconstruction for real-time applications. The algorithm presented uses a local feature detector, 19 speeded up robust features (SURF), to perform detection of brachytherapy seed 2D projections 20 from images, allowing for robust seed identification. Initial results have been obtained with 21 datasets of 30, 96 and 98 I-125 brachytherapy seeds implanted into a prostate gel phantom. It 22 can detect 97% of seeds and correctly match 97% of seeds. The average overall computation 23 time of 2.75 s...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research