Desmopressin with four-factor prothrombin complex concentrate for life-threatening bleeding: A case series

There are multiple disease states that warrant the use of anticoagulation with one or more antiplatelet agents. Additionally, direct oral anticoagulants (DOACs) are gradually replacing warfarin as the anticoagulants of choice [1]. A major complication of anticoagulant and antiplatelet therapy may be life-threatening bleeding, resulting in a debilitating state or death. Current guidelines recommend the use of four-factor prothrombin complex concentrate (4F-PCC) for anticoagulation reversal in patients experiencing major bleeding or necessitating urgent surgical intervention due to warfarin use [1,2].
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research