Multiregional sequence revealed SMARCA4 R1192C mutant clones acquired EGFR C797S mutation in the metastatic site of an EGFR-mutated NSCLC patient

Cancer evolves from a single cell that undergoes transformation and acquires a strong proliferative capacity through several genetic alterations, including somatic mutations, chromosomal copy-number alterations, dynamic changes in chromosome number and structure, and epigenetic instability (1,2). Cancer founder cells are characterized by a strong proliferative capacity; thus, they expand to compete with neighboring normal cells. This expansion is influenced by the surrounding tumor microenvironment, including the immune system (3,4).

Source: Lung Cancer - August 1, 2020 Category: Cancer & Oncology Authors: Kei Kunimasa, Yosuke Hirotsu, Yoshihiro Miyashita, Taichiro Goto, Kenji Amemiya, Hitoshi Mochizuki, Ikuko Samamoto, Takamasa Ohki, Toshio Oyama, Keiichiro Honma, Fumio Imamura, Kazumi Nishino, Toru Kumagai, Masao Omata Source Type: research