Exploring the chemical profile of designer drugs by ESI(+) and PSI(+) mass spectrometry —An approach on the fragmentation mechanisms and chemometric analysis

AbstractThe consumption of design drugs, frequently known as new psychoactive substances (NPS), has increased considerably worldwide, becoming a severe issue for the responsible governmental agencies. These illicit substances can be defined as synthetic compounds produced in clandestine laboratories in order to act as analogs of schedule drugs mimetizing its chemical structure and improving its pharmacological effects while hampering the control and making regulation more complicated. In this way, the development of new methodologies for chemical analysis of NPS drugs is indispensable to determine a novel class of drugs arising from the underground market. Therefore, this work shows the use of high ‐resolution mass spectrometry Fourier transform ion cyclotron resonance mass spectrometry (FT‐ICR MS) applying different ionization sources such as paper spray ionization (PSI) and electrospray ionization (ESI) in the evaluation of miscellaneous of seized drugs samples as blotter paper (n = 79) and tablet (n = 100). Also, an elucidative analysis was performed by ESI(+)MS/MS experiments, and fragmentation mechanisms were proposed to confirm the chemical structure of compounds identified. Besides, the results of ESI(+) and PSI(+) ‐FT‐ICR MS were compared with those of GC–MS, revealing that ESI(+)MS showed greater detection efficiency among the methodologies employed in this study. Moreover, this study stands out as a guide for the chemical analysis of NPS drugs, highlightin...

Source: Journal of Mass Spectrometry - July 29, 2020 Category: Chemistry Authors: Nayara A. Santos, Clebson J. Macrino, Jo ão Francisco Allochio Filho, Fernanda F. Gonçalves, Camila M. Almeida, Fabiana Agostini, Tainara Guizolfi, Sidnei Moura, Valdemar Lacerda, Paulo R. Filgueiras, Rafael S. Ortiz, Wanderson Romão Tags: RESEARCH ARTICLE Source Type: research