Cardiopulmonary Bypass Suppresses Forkhead Box O3 and Downstream Autophagy in Diabetic Human Heart.

CONCLUSIONS: Compared to non-diabetics, there was no significant upregulation of FOXO3α in diabetic patients, which could possibly explain the lack of upregulation of autophagy process after CPB. FOXO3α could potentially serve as a therapeutic target to improve cellular homeostasis.
PMID: 32712101 [PubMed - as supplied by publisher]

Source: The Annals of Thoracic Surgery - July 22, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Zhang Q, Feng R, Chaudhary O, Mahmood E, Baribeau Y, Rashid R, Khabbaz KR, Chu LM, Liu DC, Senthilnathan V, Cassavaugh J, Mahmood F, Robson SC, Matyal R Tags: Ann Thorac Surg Source Type: research