Hypolipidemic Lactone Derivatives from Highland Barley Monascus

A new lactone, named 9-allyl-5-methyl-1H-difuro-isochromene-1,8-dione (1), together with nine known lactone derivatives (2 –10), was isolated from highland barley Monascus for the first time. Compounds1 –10 were studied by spectroscopic methods and comparison with references and evaluated for their hypolipidemic activities by measuring the triglyceride content in HepG2 cells with simvastatin as positive control. Among them, compounds1 and7 (10 μM) exhibited moderate hypolipidemic activities.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research