Artificial metalloenzymes derived from three-helix bundles.
Artificial metalloenzymes derived from three-helix bundles.
Curr Opin Chem Biol. 2015 Jan 8;25C:65-70
Authors: Tebo AG, Pecoraro VL
Abstract
Three-helix bundles and coiled-coil motifs are well-established de novo designed scaffolds that have been investigated for their metal-binding and catalytic properties. Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal. Here we describe recent contributions in the de novo design of metalloenzymes based on three-helix bundles and coiled-coil motifs, focusing on non-heme systems for hydrolytic and redox chemistry.
PMID: 25579452 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tebo AG, Pecoraro VL Tags: Curr Opin Chem Biol Source Type: research