Organ-on-chip model shows that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge in the developing cochlea

This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Flavia Mazzarda, Annunziata D'Elia, Roberto Massari, Adele De Ninno, Francesca Romana Bertani, Luca Businaro, Gaia Ziraldo, Veronica Zorzi, Chiara Nardin, Chiara Peres, Francesco Chiani, Abraham Tettey-Matey, Marcello Raspa, Ferdinando Scavizzi, Alessandro Soluri, Anna Maria Salvatore, Jun Yang, Fabio Mammano Using microfluidics, ATP biosensors, multiphoton microscopy and genetically targeted mice, we show that ATP release through connexin hemichannels, and not pannexin 1 channels, underlies spontaneous Ca2+ wave propagation in the greater epithelial ridge of the developing cochlea. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Lab Chip latest articles - July 23, 2020 Category: Chemistry Authors: Flavia Mazzarda Source Type: research