Synthetic Study on Lactonamycins, Part 2: Stereoselective Access to ABCD-Ring System

Synlett DOI: 10.1055/s-0040-1707198 Toward a stereoselective total synthesis of the lactonamycins, we recently reported an approach to the DEF-ring system. Here we report a model study for constructing the ABCD-ring system, revealing a viable approach through (1) construction of the C-ring by asymmetric benzoin cyclization, (2) introduction of an angular hydroxy group through oxidation of an isoxazolium salt, and (3) construction of the AB rings through a ring-opening/closing sequence. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - July 20, 2020 Category: Chemistry Authors: Takikawa, Hiroshi Murata, Kazuki Sato, Shogo Kawada, Takuma Nakakohara, Hiroshi Ohmori, Ken Suzuki, Keisuke Tags: letter Source Type: research