Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects
Breath analysis by secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS)
has potential for clinical diagnosis and drug monitoring. However, there is still a lack of
benchmarking data that shows the capability of this technique and allows comparability with other
breath analysis techniques. In this regard, the goal of this study was the identification of
volatile compounds upon ingestion of a specific peppermint oil capsule to get benchmark data for
real-time breath analysis with SESI-HRMS. This was done in the framework of a consortium set up by
the International Association of Breath Research (IABR), aimed at comparing several analytical
instruments for breath analysis. Breath temporal profiles of two subjects were analyzed with
SESI-HRMS before and after ingestion of a peppermint oil capsule. The measurements were performed at
two different locations using identical SESI-HRMS platforms to allow for comparability and
benchmarking. Remarkably, al...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Amanda Gisler, Jiayi Lan, Kapil Dev Singh, Jakob Usemann, Urs Frey, Renato Zenobi and Pablo Sinues Source Type: research