IL-10 treatment decreases blood pressure in male, but not female, spontaneously hypertensive rats.

In conclusion, despite male SHR having less IL-10 and IL-10 receptor expression in the kidney compared to females, exogenous IL-10 selectively decreased BP only in males. Furthermore, our data suggests that exogenous IL-10-induced decreases in BP in male SHR are not dependent on upregulating renal NOS activity.
PMID: 32686523 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - July 19, 2020 Category: Physiology Authors: Gillis EE, Musall JB, Baban B, Sullivan JC Tags: Am J Physiol Renal Physiol Source Type: research