Metabolomic profiling of mouse mammary tumor-derived cell lines reveals targeted therapy options for cancer subtypes

ConclusionsOur results demonstrate the feasibility of metabolic profiling to develop novel personalized therapy strategies for different subtypes of breast cancer.Graphical abstractSchematic overview of the experimental design for drug selection based on breast cancer subtype-specific metabolism. The epithelial mesenchymal transition (EMT) and papillary tumors are histologically distinct mouse mammary tumor subtypes from the MMTV-Myc mouse model. Cell lines derived from tumors can be used to determine metabolic pathways that can be used to select drug candidates for each subtype.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research