Neuroprotective Efficiency of Cyclosporine After Traumatic Brain Injury in Rats.

CONCLUSION: The results demonstrated that systemic administration of cyclosporine produces a statistically significant decrease in both the level of brain edema and lipid peroxidation ratio when compared with "no treatment". Cyclosporine, which is regularly used as an immunosuppressant agent, is also known to prevent opening of the mitochondrial permeability transition pore by unbinding mitochondrial matrix cyclophilin. Regulation of transition pore for mitochondrial permeability by cyclosporine implies that mitochondrial dysfunction following traumatic brain injury is an important event in the progressive loss of neuronal tissue. PMID: 32672343 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32672343?dopt=Abstract

Source: Turkish Neurosurgery - July 18, 2020 Category: Neurosurgery Authors: Gurcan O, Uckun MO, Celikmez RC, Turkoglu OF, Eroglu H, Beskonakli E, Oner L, Taskin Y Tags: Turk Neurosurg Source Type: research