Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells [Medical Sciences]

Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked disorder associated with cognitive impairment. Although...

Source: Proceedings of the National Academy of Sciences - July 13, 2020 Category: Science Authors: Lorenza Garribba, Victoria A. Bȷerregaard, Marisa M. Goncalves Dinis, Ozgun Ozer, Wei Wu, Despoina Sakellariou, Javier Pena–Diaz, Ian D. Hickson, Ying Liu Tags: Biological Sciences Source Type: research