A four week trial of hypertonic saline in children with mild cystic fibrosis lung disease: Effect on mucociliary clearance and clinical outcomes

The absence of cystic fibrosis transmembrane regulator (CFTR) protein function results in dehydration of airway secretions in patients with CF [1]. Over time, CF airway secretions progressively obstruct airway lumens and serve as the nidus of chronic airway infection. Strategies that reverse airway service liquid (ASL) dehydration and support mucus transport, therefore, address the primary pathogenesis of CF lung disease and are expected to improve clinical outcomes [2].

Source: Journal of Cystic Fibrosis - July 11, 2020 Category: Respiratory Medicine Authors: Scott H. Donaldson, T. Danielle Samulski, Caroline LaFave, Kirby Zeman, Jihong Wu, Aaron Trimble, Agathe Ceppe, William D. Bennett, Stephanie D. Davis Source Type: research