Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design

Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Eva Calvo-Pinilla, Alejandro Marín-López, Sergio Utrilla-Trigo, Luís Jiménez-Cabello, Javier Ortego
Source: Current Opinion in Virology - Category: Virology Source Type: research

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Authors: Lackland DT, Sims-Robinson C, Jones Buie JN, Voeks JH Abstract The randomized clinical trial (RCT) has long been recognized as the 'gold standard' for developing evidence for clinical treatments and vaccines; however, the successful implementation and translation of these findings is predicated upon external validity. The generalization of RCT findings are jeopardized by the lack of participation of at-risk groups such as African Americans, with long-recognized disproportional representation. Distinct factors that deter participation in RCTs include distrust, access, recruitment strategies, perceptions of ...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
With prospects of a Covid-19 vaccine looking up, attention is turning to the problem of anti-vax ideas. The number of conspiracy theories circulating about coronavirus don't help. Here are six rules an expert uses for talking to conspiracy theorists in an effort to change their mind.
Source: - Health - Category: Consumer Health News Source Type: news
Local Covid-19 drugmaker CureVac has firmed up its executive team in advance of its much-anticipated IPO.   CureVac, which is based in Germany with U.S. headquarters in Boston, announced Tuesday that Dr. Franz-Werner Haas will become its permanent CEO. He stepped into the role on a temporary basis in March after a week in which CureVac went through two chief executives.  The company has also lured I gor Splawski over from the Novartis Institutes for Biomedical Research in Cambridge to serve as…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Condition:   COVID-19 Interventions:   Biological: Two COVID-19 vaccine candidate (TMV-083) administrations - Low dose;   Biological: Two COVID-19 vaccine candidate (TMV-083) administrations - High dose;   Biological: One COVID-19 vaccine candidate (TMV-083) administration - High dose;   Other: Placebo Sponsors:   Institut Pasteur;   Themis Bioscience GmbH;   Coalition for Epidemic Preparedness Innovations (CEPI) Not yet recruiting
Source: - Category: Research Source Type: clinical trials
This study evaluated the real-world vaccine effectiveness of 1, 2, or 3 doses of HPV vaccine against the development of high-grade cervical lesions.American Journal of Epidemiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
Condition:   Coronavirus Disease (COVID-19) Interventions:   Biological: V591;   Other: Placebo Sponsor:   Merck Sharp & Dohme Corp. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
As some youth sports teams get started again, some summer camps and daycares are opening up, and we begin to think about school (or some form of it) in the fall, many parents are wondering: what do I do about getting that physical form I need for my child? Understandably, many families do not want to go to the doctor right now. They are worried about going anywhere, and especially worried about going to a medical office, where they are concerned they may end up around sick people. I want to say up front that most medical facilities are very aware of the risk, and take measures to make sure that patients can safely get the ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Children's Health Parenting Source Type: blogs
Abstract Heroin overdose and addiction remain significant health and economic burdens in the world today costing billions of dollars annually. Moreover, only limited pharmacotherapeutic options are available for treatment of heroin addiction. In our efforts to combat the public health threat posed by heroin addiction, we have developed vaccines against heroin. To expand upon our existing heroin-vaccine arsenal, we synthesized new aryl and alkyl sulfonate ester haptens; namely aryl-mono-sulfonate (HMsAc) and Aryl/alkyl-di-sulfonate (H(Ds)2) as carboxyl-isosteres of heroin then compared them to our model heroin-hapt...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
Abstract The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening global health. The virus emerged in late 2019 and can cause a severe disease associated with significant mortality. Several vaccine development and drug discovery campaigns are underway. The SARS-CoV-2 main protease is considered a promising drug target, as it is dissimilar to human proteases. Sequence and structure of the main protease are closely related to those from other betacoronaviruses, facilitating drug discovery attempts based on previous lead compounds. Covalently binding peptidomimetic...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
This study was conducted to investigate the effect of chemical components as supplements using the experimental design method, which aimed at reducing the number of experiments. For this purpose, supplements including chemical components using four levels, with three replications in suspension and batch culture conditions, were examined for 72 hours using the Taguchi experimental design method. From the experiments, it was concluded that the culture media composition had a significant impact on final cell count and pH. High concentrations of different media composition alone were insufficient to ensure higher cell count. A...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
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