Pattern of Recurrent Inflammation following Anti-tubercular Therapy for Ocular Tuberculosis.
Pattern of Recurrent Inflammation following Anti-tubercular Therapy for Ocular Tuberculosis. Ocul Immunol Inflamm. 2020 Jul 09;:1-6 Authors: Multani PK, Modi R, Basu S Abstract PURPOSE: To investigate recurrence patterns following anti-tubercular therapy (ATT) in different anatomical presentations of ocular tuberculosis (OTB). METHODS: Retrospective analysis of clinically diagnosed OTB patients divided anatomically into groups A (anterior + intermediate uveitis) and B (posterior + panuveitis). Recurrence was defined as reappearance of intraocular inflammation in a quiescent eye following completion of at least 6-months ATT. Anatomical sites of recurrence were compared to that of presentation. RESULTS: No significant difference in post-ATT recurrent inflammation was noted between groups A (14.29%, 4/28) and B (8.59%,11/128) (p = .57). Mean follow up was 13.13 ± 14.67 months. All group A recurrences were in the same anatomical segment, whereas in group B, 41.7% (5/11) recurrences were in group A sites. Overall, the group A:B ratio was significantly higher during recurrent inflammation (8:7) than at presentation (28:128) (p
This study aimed to investigate the use of fiberoptic bronchoscopy and bronchoalveolar lavage in the diagnosis of pulmonary pathogenic microorganism infection in AIDS patients. We retrospectively analyzed the clinical data, fiberoptic bronchoscopy and bronchoalveolar lavage fluid laboratory examinations of 209 AIDS patients with pulmonary infection. Among 209 patients, we found 42 cases of mycobacterial infection, 3 cases of bacterial infection, 58 cases of pneumocystis carinii pneumonia (PCP), 27 cases that were fungal positive, 99 cases of CMV, and 103 cases positive for GM test of which 83 cases were considered Aspergil...
g T Abstract Tuberculosis (TB) is a chronic inflammatory infectious disease caused by Mycobacterium tuberculosis (Mtb), which induces irreversible pulmonary damage. Oxysophocarpine (OSC) is a natural alkaloid that exhibits multiple pharmacological activities, including anti-inflammation; however, the protective effects of OSC against TB and the mechanisms involved are unknown. Here, we established murine and cellular models of TB with C3HeB/FeJ mice and neutrophils infected with H37Rv to investigate the biological functions of OSC in TB. We found that OSC reduced the mortality, inhibited the pulmonary H37Rv growth...
CONCLUSION: micronutrient intervention during tuberculosis treatment has a positive effect toward to sputum conversion among patient. Zinc and retinol influence sputum conversion while vitamin D did not. PMID: 32778625 [PubMed - in process]
Authors: Díaz-Valle D, Burgos-Blasco B, Vergas-Garcia J PMID: 32778431 [PubMed - as supplied by publisher]
This report describes an investigation of three cases of multidrug-resistant tuberculosis that occurred at two food processing facilities in Ohio.
We present a case of a patient with metastatic nasopharyngeal carcinoma treated with avelumab, a programmed cell death-ligand 1 inhibitor with resulting laryngeal TB as the presenting symptom of reactivated TB. The patient required quadruple anti-TB therapy, but developed ongoing sequelae of laryngeal TB, including dysphagia and laryngeal stenosis. Ongoing trials are examining the use of avelumab in head and neck cancer patients with locally advanced disease, recurrent, or metastatic disease. Awareness of the risk of new and reactivated TB is crucial.
Authors: Akhaddar A, Rharrassi I Abstract This is a rare case report about hypertrophic cranial pachymeningitis coinfection with tuberculosis and actinomycosis in a 35-year-old male. The patient presented with progressive headache, paraesthesia, and blurred vision. Dural biopsy, histology, and cultures are imperative in pachymeningitis for establishing the diagnosis and guiding treatment. PMID: 32754372 [PubMed]
Publication date: Available online 9 August 2020Source: Research in Veterinary ScienceAuthor(s): V. Guétin-Poirier, J. Rivière, G. Crozet, B. Dufour
Publication date: Available online 5 August 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Steven E. Trasino, Xiao-Han Tang, Carolina Trujillo, Jaclynn Andres, Sabine Ehrt, Lorraine J. Gudas
Publication date: Available online 6 August 2020Source: Journal of Theoretical BiologyAuthor(s): Michael J. Pitcher, Ruth Bowness, Simon Dobson, Raluca Eftimie, Stephen H. Gillespie