Localized Granulomatous with Polyangiitis (GPA): Varied Clinical Presentations and Update on Treatment

The objective of this review is to summarize the various clinical manifestations of localized disease in GPA and their treatment.Recent FindingsSinonasal disease is seen in up to 90% of patients. Otologic and ocular involvement is also commonly seen. Laryngeal and tracheal disease although less common is associated with significant morbidity and can be therapeutically challenging. Clinicians need to be aware of these localized GPA manifestations as they may be presenting disease features in the absence of other systemic findings. Treatment of localized GPA involves both immunosuppressive and surgical interventions for specific manifestations. Collaboration between specialists including rheumatologists, otolaryngologists, and ophthalmologists is often crucial to ensure optimal outcomes for patients.SummaryThis is a narrative review that provides a comprehensive overview of localized granulomatosis with polyangiitis and current treatment options.

Source: Current Allergy and Asthma Reports - July 8, 2020 Category: Allergy & Immunology Source Type: research