T cell dynamics in chronic lymphocytic leukemia under different treatment modalities.

CONCLUSIONS: Taken together, our NGS immunoprofiling data suggest that BcRi retain T cell clones that may have developed against CLL-associated antigens. Phenotypic and immune synapse bioassays support a concurrent restoration of functionality, mostly evident for R-ID, arguably contributing to clinical response.
PMID: 32616500 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - July 1, 2020 Category: Cancer & Oncology Authors: Vardi A, Vlachonikola E, Papazoglou D, Psomopoulos F, Kotta K, Ioannou N, Galigalidou C, Gemenetzi K, Pasentsis K, Kotouza M, Koravou E, Scarfò L, Iskas M, Stavroyianni N, Ghia P, Anagnostopoulos A, Kouvatsi A, Ramsay AG, Stamatopoulos K, Chatzidimitriou Tags: Clin Cancer Res Source Type: research