Leukocyte-Dependent Effects of Platelet Rich Plasma on Cartilage Loss and Thermal Hyperalgesia in a Mouse Model of Post-Traumatic Osteoarthritis

Platelet-rich plasma (PRP) is an emerging therapeutic strategy for treatment of osteoarthritis (OA); however, there is a lack of preclinical and clinical evidence for its efficacy and its mechanism of action is unclear. In the current study, we utilized leukocyte poor-PRP (LP-PRP) and leukocyte rich-PRP (LR-PRP) to mimic clinical point of care formulations and assessed their potential to alter disease progression in a mouse model of post-traumatic OA.

Source: Osteoarthritis and Cartilage - July 2, 2020 Category: Rheumatology Authors: Prathap Jayaram, Christina Liu, Brian Dawson, Shamika Ketkar, Shiv J. Patel, Brendan H. Lee, Matthew W. Grol Source Type: research