Chemerin reactivates PTEN and suppresses PD-L1 in tumor cells via modulation of a novel CMKLR1-mediated signaling cascade.

CONCLUSIONS: Collectively, our data show a novel link between chemerin, PTEN and PD-L1 in human tumor cells, that may have a role in improving T cell-mediated immunotherapies. PMID: 32605911 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research