Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.

In conclusion, circ-AKT3 inhibited the extracellular matrix accumulation in diabetic nephropathy mesangial cells through modulating miR-296-3p/E-cadherin signals, which might offer novel potential opportunities for clinical diagnosis targets and therapeutic biomarkers for diabetic nephropathy.
PMID: 32597022 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - June 27, 2020 Category: Molecular Biology Authors: Tang B, Li W, Ji TT, Li XY, Qu X, Feng L, Bai S Tags: J Cell Mol Med Source Type: research