Deterioration of Nighttime Respiratory Mechanics in Chronic Obstructive Pulmonary Disease: Impact of Bronchodilator Therapy.

Deterioration of Nighttime Respiratory Mechanics in Chronic Obstructive Pulmonary Disease: Impact of Bronchodilator Therapy. Chest. 2020 Jun 27;: Authors: Domnik NJ, James MD, Scheeren RE, Ayoo GA, Taylor SM, Di Luch AT, Milne KM, Vincent SG, Phillips DB, Elbehairy AF, Crinion SJ, Driver HS, Neder JA, O'Donnell DE Abstract BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is associated with nighttime respiratory symptoms, poor sleep quality, and increased risk of nocturnal mortality. Overnight deterioration of inspiratory capacity (IC) and forced expiratory volume in 1 second (FEV1) have previously been documented. However, the precise nature of this deterioration and mechanisms by which evening bronchodilators may mitigate this have not been studied. RESEARCH QUESTION: To determine the effect of evening dosing of dual, long-acting bronchodilators on detailed nocturnal respiratory mechanics and inspiratory neural drive (IND). STUDY DESIGN: A double-blind, randomized, placebo-controlled crossover study assessed the effects of evening long-acting bronchodilators (BD; aclidinium bromide/formoterol fumarate dihydrate, 400/12 mcg) or placebo (PL) on morning trough IC (12 hours post-dose; primary outcome) and serial overnight measurements of spirometry, dynamic respiratory mechanics and IND (secondary outcomes). METHODS: 20 participants with COPD (moderate/severe airway obstruction and lung hyperinflation) un...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research