High-Scatter Lymphocytes in the Blood of Erythrodermic Cutaneous T-Cell Lymphoma: Evidence for Large-Cell Transformation?

Increasing number of large cells in the peripheral blood of patients with erythrodermic cutaneous T-cell lymphoma may reflect large-cell transformation. We found that flow cytometry accurately detected high-scatter T lymphocytes in initial blood samples from 10 of 19 patients with S ézary syndrome, 1 of 13 patients with erythrodermic mycosis fungoides, and no patient with nonneoplastic inflammatory conditions. The presence of high-scatter lymphocytes suggests a poor prognosis even for patients with advanced disease.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research