Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study.

Conclusions: Supplementation of SAMe and L. plantarum HEAL9 in adults with subthreshold or mild-to-moderate symptoms of depression resulted in fast and clinically relevant effects after 2 weeks. The combination was safe and significantly improved symptoms of depression, anxiety, and cognitive and somatic components. The effect of this novel product is independent from the severity of the symptoms unlike traditional antidepressants available on the market that have minimal benefits for subthreshold or mild-to-moderate symptoms. Trial Registration: ClinicalTrials.gov identifier: NCT03932474. PMID: 32589828 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32589828?dopt=Abstract

Source: The Primary Care Companion for CNS Disorders - June 28, 2020 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research