Indole alkaloids with potential anticancer activity.

Indole alkaloids with potential anticancer activity. Curr Top Med Chem. 2020 Jun 22;: Authors: Xu D, Xu Z Abstract Indole alkaloids which are abundance in nature are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert the anticancer activity via various antiproliferative mechanisms, and some of them such as Vinblastine and Vincristine have already used in clinic or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship and mechanisms of action covering the articles published from 2015 to 2020. PMID: 32568021 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research