IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis

Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called IRE1A) is a sensor of the unfolded protein response that is activated in livers of patients with nonalcoholic steatohepatitis (NASH). Hepatocytes release ceramide-enriched inflammatory extracellular vesicles (EVs) following activation of IRE1A. We studied the effects of inhibiting IRE1A on release of inflammatory EVs in mice with diet-induced steatohepatitis.

Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Debanjali Dasgupta, Yasuhiko Nakao, Amy S. Mauer, Jill M. Thompson, Tejasav S. Sehrawat, Chieh-Yu Liao, Anuradha Krishnan, Fabrice Lucien, Qianqian Guo, Mengfei Liu, Fei Xue, Masanori Fukushima, Tomohiro Katsumi, Aditya Bansal, Mukesh K. Pandey, Jessica L Source Type: research