A critical update on the strategies towards modulators targeting androgen receptors.

A critical update on the strategies towards modulators targeting androgen receptors.
Bioorg Med Chem. 2020 Jul 01;28(13):115554
Authors: Luan H, Xu P, Meng Y, Li Z, Bian J
Abstract
Prostate cancer is the most common carcinoma of the male urinary system in developed countries. Androgen deprivation therapy has been commonly used in the treatment of prostate cancer for decades, but most patients will inevitably develop into more aggressive castration-resistant prostate cancer. Therefore, novel strategies are urgent to address this resistance mechanism. In this review, we discussed some new strategies for targeting androgen receptors through degradation pathways as potential treatments for prostate cancer.
PMID: 32546299 [PubMed - in process]

Source: Bioorganic and Medicinal Chemistry - June 18, 2020 Category: Chemistry Authors: Luan H, Xu P, Meng Y, Li Z, Bian J Tags: Bioorg Med Chem Source Type: research