Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor.

CONCLUSIONS: Our results suggest that binding of FVIII to D'D3 and/or A2 may alter the mechanical property in the central A2 domain. The findings provide novel insight into the molecular mechanism underlying FVIII-dependent regulation of VWF proteolysis by ADAMTS13 under mechanical force.
PMID: 32544272 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - June 15, 2020 Category: Hematology Authors: Cao W, Cao W, Zhang W, Zheng XL, Zhang XF Tags: J Thromb Haemost Source Type: research