36. Quadruple-hit B-cell lymphoma with simultaneous BCL2, BCL6, CCND1, and MYC rearrangements: Two new cases

The WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues has a section on high-grade B-cell lymphoma (HGBL) with MYC translocations, which includes double/triple-hit lymphomas characterized by MYC and BCL2 and/or BCL6 rearrangements, as well as other aggressive lymphomas without a MYC translocation that have a blastoid morphology or a morphology intermediate between DLBCL and BL (HGBL, NOS). 'Quadruple-hit' cases, defined by the presence of MYC, BCL2, BCL6, and CCND1 rearrangements, are rare; only three cases have been reported (1,2).

Source: Cancer Genetics and Cytogenetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Aurelia Meloni-Ehrig, Zunyan Dai, Nathan Bohls, Michal Konarkowski, Patricia Stone, Martha Valenzuela, Alicia Tamayo, Zhenjun Lou, Kaye Siragusa, Dana Delgado, Catherine Li, Leilani Manera, Antonette Smith-Mitchell, Adrienne Kim, Claudia Kraemer, Stephani Source Type: research