688 Keratinocyte behaviour in normal appearing vitiligo skin

Cytoarchitectonic and functional interactions among epidermal and dermal compartments are known to regulate melanocyte behaviour and survival. The presence of a deregulated microenvironment able to affect melanocyte homeostasis has been described in both hyper- and hypo-pigmentary disorders. In vitiligo, several data indicate a structural and functional impairment not only of melanocytes, but also of the other cutaneous cells, which appears broadly extended, even in apparently normal skin. In line with these remarks, our group has recently reported some modifications in non lesional fibroblasts, which show a myofibroblast phenotype associated to signs of premature senescence.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research