733 SFRP2-expressing, COL11A1-expressing fibroblasts are the major fibroblast population within keloids

Fibroblasts perform a multitude of processes within skin: extracellular matrix (ECM) production, regulation of inflammation, facilitate cutaneous repair after injury, and serve as pluripotent mesenchymal cells. Recent evidence suggests that there are two main major fibroblast populations in human skin: SFRP2-expressing fibroblasts and FMO1-expressing fibroblasts, and five minor populations, each expressing discrete genes: CRABP1, COL11A1, FMO2, PRG4, or C2ORF40. Keloids are benign fibroproliferative tumors that result from an exaggerated response to cutaneous wound healing.

Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: I. Dougherty, V. Cantu, D. Glass Tags: Skin of Color Source Type: research