Association of Benzodiazepines and Antidepressants With 180-Day Mortality Among Patients With Dementia Receiving Antipsychotic Pharmacotherapy: A Nationwide Registry-Based Study.

CONCLUSIONS: The diverse impact of concomitant use of benzodiazepines and antidepressants on mortality may be due to a direct drug-related effect. Alternatively, the findings could reflect differential mortality associated with different indications for therapy. Although the results cannot prove causality, and there may be residual confounding, clinicians should be cautious when considering the combination of antipsychotics and benzodiazepines in patients with dementia. PMID: 32526104 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32526104?dopt=Abstract

Source: Journal of Clinical Psychiatry - June 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research