Flow Augmentation in the Myocardium by Ultrasound Cavitation of Microbubbles: Role of Shear-Mediated Purinergic Signaling

Ultrasound-mediated cavitation of microbubble contrast agents produces high intravascular shear. We hypothesized that microbubble cavitation increases myocardial microvascular perfusion through shear-dependent purinergic pathways downstream from ATP release that is immediate and sustained through cellular ATP channels such as Pannexin-1.

Source: Journal of the American Society of Echocardiography - June 8, 2020 Category: Cardiology Authors: Federico Moccetti, Todd Belcik, Yllka Latifi, Aris Xie, Koya Ozawa, Eran Brown, Brian P. Davidson, William Packwood, Azzdine Ammi, Sabine Huke, Jonathan R. Lindner Source Type: research