CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.

CONCLUSION: These findings establish CTCF loss as a major mediator in directing localized DNA hypermethylation events in a tissue-specific fashion and further support its role as a driver of the cancer phenotype.
PMID: 32503656 [PubMed - as supplied by publisher]

Source: Clinical Genitourinary Cancer - June 4, 2020 Category: Cancer & Oncology Authors: Damaschke NA, Gawdzik J, Avilla M, Yang B, Svaren J, Roopra A, Luo JH, Yu YP, Keles S, Jarrard DF Tags: Clin Epigenetics Source Type: research