Naringin inhibits titanium particles-induced up-regulation of TNF- α and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane.

CONCLUSIONS: These results indicated that naringin could inhibit Ti particle-induced inflammation in fibroblasts by inhibiting p38 MAPK/NF-κB p65 activity and might be a potential drug for the treatment of inflammatory periprosthetic osteolysis after arthroplasty.
PMID: 32500755 [PubMed - as supplied by publisher]

Source: Connective Tissue Research - June 7, 2020 Category: Research Tags: Connect Tissue Res Source Type: research