Introduction

Interventional Oncology has evolved and grown into a distinct subspecialty of Interventional Radiology and ablation technologies are a critical component of this growth. From the early beginnings of alcohol ablation to latest addition of irreversible electroporation, ablation has changed cancer management in ways that could not have been imagined just a few decades ago.
Source: Techniques in Vascular and Interventional Radiology - Category: Radiology Authors: Source Type: research

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Liquid-based cytology (LBC) is now a widely used method for cytologic screening and cancer diagnosis. Since the cells are fixed with alcohol-based fixatives, and the specimens are stored in a liquid condition,...
Source: BMC Medical Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
Regular weekly physical activity was associated with reduced mortality risks related to alcohol intake and cancers.Medscape Medical News
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Hematology-Oncology News Source Type: news
Abstract Culicinin D (1), a 10 amino acid peptaibol containing several unusual residues, has been shown to exhibit potent anticancer activity. Previous work in our group towards developing a structure-activity relationship (SAR) for this peptaibol has concentrated on replacement of the synthetically challenging AHMOD (3) and AMD (4) residues, resulting in the discovery of analogues with equivalent or better potency and simplified synthesis. The SAR of this peptaibol is extended in this work by investigating the effect of the N-terminal lipid tail and C-terminal amino alcohol, revealing the key contribution of each...
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Tags: Bioorg Med Chem Lett Source Type: research
This study aimed to clarify the risk factors of head and neck cancer (HNC) mortality, relative to those of all-cause and all-cancer mortalities, using the Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data set. Data from 238 HNC deaths, 14,769 all-cancer deaths, and 38,086 all-cause deaths were extracted during a median follow-up period of 9.5 years. Baseline characteristics were assessed via chi-square tests, t tests, and multivariable logistic regression. HNC mortality was found to be positively associated with male sex, past and current smoking habits, moderate-to-heavy alcohol consumptio...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
elmohsen Hassan Premna odorata Blanco (Lamiaceae) is an ethnomedicinal plant native to different tropical regions. Although some reports addressed their anti-inflammatory, cytotoxic, and antituberculotic effects, their hepatoprotective potential is yet to be discovered. Accordingly, this study investigated the crude extract and different fractions of the plant leaves; metabolic profiling using liquid chromatography / high-resolution electrospray ionization mass spectroscopy (LC–HRESIMS) analysis, in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties for the dereplicated...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol‑associated hepatocellular carcinoma using weighted gene co‑expression network analysis. Oncol Rep. 2020 Aug;44(2):611-627 Authors: Bi N, Sun Y, Lei S, Zeng Z, Zhang Y, Sun C, Yu C Abstract Alcohol‑associated hepatocellular carcinoma (HCC) is a subtype of HCC with poor prognosis. The present study aimed to identify key biomarkers for alcohol‑associated HCC. The gene data profiles and corresponding clinical traits of patients with alcohol‑associated HCC were downloaded from The Cancer Genome Atlas (TCGA) database. First...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
CONCLUSIONS: The present study implied possible DEGs, especially the new gene CEP192, in the progression of NAFLD developing to HCC. Further rigorous experiments are required to verify the above results. PMID: 32623384 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Does religion help or harm people with severe mental illness? In today’s Not Crazy podcast, Gabe and Lisa welcome Rachel Star Wither, host of the Inside Schizophrenia podcast, to discuss religion’s role (or lack thereof) in treating those struggling with schizophrenia or bipolar disorder. Rachel relates her personal experiences of mixing religion with her illness and shares how she currently manages to believe in God while keeping her faith “separate” from her symptoms. Tune in for a deep discussion on religion and severe mental illness, including Rachel’s 3-day exorcism experience at age 17....
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders General Interview Not Crazy Podcast Schizophrenia Spirituality Source Type: blogs
N6-Methyladenosine (m6A) is the most common RNA internal modification in eukaryotic cells. Its regulatory effects at the post-transcriptional level on both messenger RNAs (mRNAs) and noncoding RNAs have been widely studied; these include alternative splicing, stability, translation efficiency, nucleus export, and degradation. m6A modification is implicated in a series of physiological and pathological activities, such as embryonic stem cell differentiation, immunoregulation, adipogenesis, and cancer development. Recently, the significance of m6A methylation has been identified in both viral hepatitis and non-alcohol fatty ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Molecules, Vol. 25, Pages 3093: The GABAB Receptor—Structure, Ligand Binding and Drug Development Molecules doi: 10.3390/molecules25133093 Authors: Linn Samira Mari Evenseth Mari Gabrielsen Ingebrigt Sylte The γ-aminobutyric acid (GABA) type B receptor (GABAB-R) belongs to class C of the G-protein coupled receptors (GPCRs). Together with the GABAA receptor, the receptor mediates the neurotransmission of GABA, the main inhibitory neurotransmitter in the central nervous system (CNS). In recent decades, the receptor has been extensively studied with the intention being to understand pathophysiologi...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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