Hypersensitivity to atypical antipsychotics in dementia with Lewy bodies: is it common or rare?

Hypersensitivity to antipsychotics is one of the known clinical features of dementia with Lewy bodies (DLB). The prevalence of hypersensitivity in DLB patients is known to be relatively high ranging from 30 to 50% [1]. Published in 2017, the revised diagnostic criteria for DLB suggested a reduction in the diagnostic usefulness of antipsychotic hypersensitivity [2,3]. Specifically, antipsychotic hypersensitivity is now listed as a supportive, rather than suggestive, clinical feature. This revision was due to the decrease in the use of typical antipsychotics such as dopamine receptor D2 antagonists [3,4].

Source: Parkinsonism and Related Disorders - June 5, 2020 Category: Neurology Authors: Jung-Min Pyun, Young Ho Park, Jimin Yang, Nayoung Ryoo, SangYun Kim Tags: Correspondence Source Type: research