Disposition and Metabolism of 2,2'-Dimorpholinodiethyl Ether in Sprague Dawley Rats and B6C3F1/N Mice after Oral, Intravenous Administration, and Dermal Application.

Disposition and Metabolism of 2,2'-Dimorpholinodiethyl Ether in Sprague Dawley Rats and B6C3F1/N Mice after Oral, Intravenous Administration, and Dermal Application. Xenobiotica. 2020 Jun 05;:1-33 Authors: Waidyanatha S, McDonald JD, Sanders JM, Doyle-Eisele M, Moeller BC, Garner CE Abstract The specialty amine catalyst 2,2'-dimorpholinodiethyl ether (DMDEE) is a high-production volume chemical used in the production of flexible foam, high-resilient molded foam, and in coatings and adhesives. The disposition and metabolism of [14C]DMDEE (20 or 200 mg/kg) were determined in male ane female rats and mice after oral and intravenous administration and dermal application.In male and female rats, following a single oral administration, [14C]DMDEE was well-absorbed and excreted rapidly and extensively via urine (75-93%) and some in feces (∼ 4-8%). The total radioactivity in tissues at 24 h and 72 h (males only) following oral administration was 8 -10% and ∼4%, respectively, suggesting considerable tissue distribution. A moderate amount of the total tissue radioactivity in kidney and liver were unextractable suggesting covalent binding of [14C]DMDEE-derived products in tissue macromolecules.Absorption following a single dermal application in rats was significant (∼ 64%) with a similar disposition pattern to oral.The oral and dermal disposition of [14C]DMDEE in male and female mice was similar to rats.Urinary products of DMDEE ide...
Source: Xenobiotica - Category: Research Authors: Tags: Xenobiotica Source Type: research