Involvement of Disabled-2 on skin fibrosis in systemic sclerosis

Systemic sclerosis (SSc) is a connective tissue disease, which is featured by abnormal inflammation, extensive dermal and internal organ fibrosis [1]. It is clinically classified into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) [2]. Skin fibrosis causes various disabilities including hair loss, subcutaneous atrophy, irreversible structural and functional impairment such as joint contracture [3]. Skin fibrosis of SSc can progress over the years and lead to significant cosmetic, functional and psychological disabilities [4].

Source: Journal of Dermatological Science - June 1, 2020 Category: Dermatology Authors: Xueqian Mei, Han Zhao, Yan Huang, Yulong Tang, Xiangguang Shi, Weilin Pu, Shuai Jiang, Yanyun Ma, Yuting Zhang, Lu Bai, Wenzhen Tu, Yinhuan Zhao, Li Jin, Wenyu Wu, Jiucun Wang, Qingmei Liu Source Type: research