Protective effects of Fc-fused PD-L1 on two different animal models of colitis

Conclusions
Based on the protective effect of PD-L1-Fc against DSS-induced and T-cell-induced colitis, our results suggest that PD-1-mediated inhibitory signals have a crucial role in limiting the development of colonic inflammation. This implicates that PD-L1-Fc may provide a novel therapeutic approach to treat inflammatory bowel disease.

Source: Gut - January 8, 2015 Category: Gastroenterology Authors: Song, M.-Y., Hong, C.-P., Park, S. J., Kim, J.-H., Yang, B.-G., Park, Y., Kim, S. W., Kim, K. S., Lee, J. Y., Lee, S.-W., Jang, M. H., Sung, Y.-C. Tags: Experimental colitis Source Type: research