Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris?

Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris? Br J Dermatol. 2020 May 29;: Authors: Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R Abstract Lichen planopilaris (LPP) is a difficult to treat condition leading to permanent hair loss and scarring. Pathobiologically, LPP shows T- cell mediated interferon-γ driven loss of keratin 15 (K15) positive hair follicle (HF) epithelial stem cells (eHFSCs) due to immune privilege (IP) collapse and pathological epithelial-mesenchymal transition (EMT). This exhausts the eHFSC pool; impacting the HF's capacity to regenerate and cycle and ultimately resulting in HF destruction, fibrosis and scarring. PMID: 32471007 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32471007?dopt=Abstract

Source: The British Journal of Dermatology - May 28, 2020 Category: Dermatology Authors: Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R Tags: Br J Dermatol Source Type: research