High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depict a new type of primary genetic dyslipidemia.

Duchenne and Becker muscular dystrophies (DMD/BMD) are allelic X-linked recessive muscle diseases caused by mutations in the DMD gene, with DMD being the more severe form. We have recently shown that increased plasma low-density lipoprotein-associated cholesterol (LDL-C) causes severe muscle wasting in the mdx mouse, a mild DMD model, which suggested that plasma lipids may play a critical role in DMD. We have also observed that loss of dystrophin in mice causes unexpected elevations in plasma lipoprotein levels.

Source: Journal of Clinical Lipidology - May 27, 2020 Category: Lipidology Authors: Zoe White, Chady H. Hakim, Marine Theret, N. Nora Yang, Fabio Rossi, Dan Cox, Gordon A. Francis, Volker Straub, Kathryn Selby, Constadina Panagiotopoulos, Dongsheng Duan, Pascal Bernatchez Tags: Original Research Source Type: research