Total synthesis of bryostatin 3

Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count.

Source: ScienceNOW - May 27, 2020 Category: Science Authors: Trost, B. M., Wang, Y., Buckl, A. K., Huang, Z., Nguyen, M. H., Kuzmina, O. Tags: Chemistry reports Source Type: news