[Mechanisms of radiation-induced lymphopenia and therapeutic impact].

[Mechanisms of radiation-induced lymphopenia and therapeutic impact]. Bull Cancer. 2020 May 22;: Authors: Cesaire M, Le Mauff B, Rambeau A, Toutirais O, Thariat J Abstract Radiation induced lymphopenia is frequent and can be severe and durable. Although lymphocytes have long been known as highly radiosensitive cells, it is poorly characterized. Radiation-induced lymphopenia seems to affect lymphocyte subpopulations differently and seems to be influenced by radiation modalities. The depth and duration of lymphopenia depend on the location of the irradiation and the volumes of treatment. Importantly, radiation-induced lymphopenia has been associated with poorer prognosis in several tumor types. The knowledge about radiation-induced lymphopenia might lead to a rethinking of the modalities of radiotherapy and new approaches to restore lymphocytes counts. PMID: 32451070 [PubMed - as supplied by publisher]
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research